Chinese scientists use drop of blood to detect cancer

By Xie Zhenqi

Scientists around the world are striving for effective detection of
cancer in the early stages, and a Chinese scientist may have found
a quick way of knowing whether malignant tumors exist in a patient’s
body, with just one drop of blood.

Luo Yongzhang and his team in Tsinghua University’s School of Life
Sciences in Beijing have successfully invented a reagent test kit of
Hsp90α for clinical use, which can diagnose multiple kinds of cancer
by analyzing a drop of human blood.

Malignant tumors in early phases can be cured but once they have spread
all over the patient’s body there is no way to save the person’s life.
However, it’s extremely difficult to be aware of cancer in its early stages,
as patients don’t show obvious symptoms and thus it can only be found in
its later stages, which is already too late, so to detect cancer early
remains a global challenge for scientists.Back in 1989, scientists have
found a kind of heat shock proteins (HSP), named Hsp90α, which existed in
human bodies and can be used as a cancer biomarker detection kit.

Scientists around the globe have been working on it since then, and more
than 10,000 journals have been published on accredited magazines, yet no
one has actually turned their research results into medical products.

However, Luo and his team seemed to have cracked the code, after working
on theproblem since 2009. The team has produced an artificial Hsp90α protein
that gains structural stability by regrouping proteins. This means they are
able to “create” the protein, in any quantity, and at any time they wish to.

The kit has since been used in clinical trials involving 2,347 patients at
eight hospitals in China. It was the first clinical trial in the world to
test if the protein could be a useful tumor biomarker for lung cancer, and
it succeeded.

Now, the kit has been certified to enter the Chinese and European markets,
24 years after Hsp90α was discovered.Cancer is a group of diseases involving
abnormal cell growth with the potential to invade or spread to other parts
of the body.

In 2015, about 90.5 million people had cancer in the world, with roughly
14.1 million new cases occurring each year. Approximately 8.8 million human
deaths, or 15.7 percent of all deaths in the world, are caused by cancer.

In China alone, 4.29 million people were detected as having cancer in 2015,
and 2.8 million of them died in that year.

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